Mobility/Mood

Agmatine

Endogenous arginine metabolite studied for pain and mood, but human evidence remains too limited for routine use.

Agmatine

Endogenous arginine metabolite studied for pain and mood, but human evidence remains too limited for routine use.

score

evidence

Caution

risk

Proven Benefits

01May reduce neuropathic pain

02May improve depressive symptoms

Chemical Forms

Recommended

Agmatine sulfate

Avoid

Blends without disclosed agmatine dose

Expert Note

Agmatine sulfate is the standard commercial form and the one used in the small human studies. Proprietary blends are hard to evaluate because the actual agmatine dose is often unclear.

Protocol

Amount

500-1500 mg

Frequency

Once or twice daily

When

Any time of day — consistency matters more than timing.

Safety & Limits

Upper Safe Limit

No established official UL; short-term human studies have used up to ~3 g/day without major safety signals

Cycling

Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data

Hypotension or antihypertensive medications — may further lower blood pressure

Glucose-lowering medications — possible additive glucose-lowering effect

Updated Invalid Date