Cognition/Mood

Aniracetam

Synthetic racetam compound studied for cognitive symptoms in older adults with vascular impairment; benefits in healthy people are unproven.

Aniracetam

Synthetic racetam compound studied for cognitive symptoms in older adults with vascular impairment; benefits in healthy people are unproven.

score

evidence

Caution

risk

Proven Benefits

01May improve cognition

02May reduce anxiety

03May improve post-stroke cognition

04May improve mood

Chemical Forms

Recommended

Aniracetam capsules or tablets

Avoid

Unverified bulk powders (purity and contaminant risk)

Expert Note

Aniracetam is a single synthetic compound with no clinically meaningful salt or ester variants. The main quality issue is purity and dose accuracy, so third-party tested capsules or tablets are preferable to loose bulk powder from unverified vendors.

Protocol

Amount

750-1500 mg

Frequency

Twice daily, morning and early afternoon

When

With meals containing fat to improve absorption; lipophilic compound.

Safety & Limits

Upper Safe Limit

1500 mg/day (highest daily dose commonly studied; long-term safety above this is unknown)

Cycling

Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data; avoid use

Seizure disorders or epilepsy — glutamate receptor modulation may affect seizure threshold

Severe renal or hepatic impairment — limited safety and metabolism data

Synergies

Citicoline

Aniracetam may increase cholinergic demand; citicoline supplies choline for acetylcholine synthesis.

Avoid Combining With

✕Alcohol (may blunt cognitive effects and increase drowsiness)
✕Anticholinergic medications (may oppose the proposed cholinergic effect)

Updated Invalid Date