howtosupplement
Digestion/Heart

Artichoke extract

Concentrated leaf extract used to relieve indigestion and bloating, with modest evidence for lowering LDL cholesterol in adults.

Artichoke extract

Artichoke extract

54
score
B
evidence
Caution
risk

Proven Benefits

01Relieves functional dyspepsia
02Lowers LDL cholesterol
03May reduce IBS symptoms
04May lower blood pressure
05May lower triglycerides

Chemical Forms

Recommended
  • Artichoke leaf extract standardized to caffeoylquinic acids
  • Extract standardized to chlorogenic acid
Avoid
  • Whole artichoke powder (lower active concentration)
  • Unstandardized extracts (inconsistent potency)
Expert Note

Standardized extracts ensure a consistent dose of caffeoylquinic acids, the compounds linked to digestive and lipid effects in clinical trials. Whole powders contain far lower active concentrations and lack trial backing.

Protocol

Amount
600-1800 mg
Frequency
Split into 2-3 doses daily
When
With meals to enhance digestive bile stimulation and reduce stomach upset.

Condition-Based Dosing

Functional dyspepsia or IBS
600-1200 mg daily in divided doses with meals for 4-8 weeks
Mild hyperlipidemia
1200-1800 mg daily for 6-12 weeks

Safety & Limits

Upper Safe Limit
No established UL; 1800-3200 mg/day of standardized extract has been used in trials without serious adverse effects (EFSA review).
Cycling
Safe for continuous use

Contraindications

Bile duct obstruction or cholestasis — artichoke stimulates bile flow and may worsen blockage
Gallstones — increased bile secretion could theoretically precipitate colic
Allergy to Asteraceae/Compositae plants (ragweed, daisy, marigold) — cross-reactivity risk

Avoid Combining With

  • ✕Bile acid sequestrants (take 2+ hours apart — may interfere with bile acid binding)
Updated Invalid Date