Hormonal

Calcium D-Glucarate

Calcium salt of D-glucaric acid that may lower beta-glucuronidase and support estrogen metabolism in adults with elevated estrogen recirculation.

Calcium D-Glucarate

Calcium salt of D-glucaric acid that may lower beta-glucuronidase and support estrogen metabolism in adults with elevated estrogen recirculation.

score

evidence

Caution

risk

Proven Benefits

01May lower beta-glucuronidase

02May shift estrogen metabolite profi

Chemical Forms

Recommended

Calcium D-glucarate

Avoid

Free D-glucaric acid (less stable and rarely sold)

Expert Note

The calcium salt is the standard supplemental form because it is stable and the version used in human studies. Free D-glucaric acid is less practical to formulate and rarely sold as a supplement.

Protocol

Amount

500-1500 mg

Frequency

Once daily; split higher daily doses if needed for tolerance.

When

With meals; larger daily doses are often split to improve tolerance.

Condition-Based Dosing

Elevated urinary estrogen metabolite profile

500 mg daily— Use as a short trial and reassess symptoms or biomarkers after 8-12 weeks.

Elevated beta-glucuronidase

1000-1500 mg daily in 2 divided doses— Human evidence is limited; split doses if GI discomfort occurs and retest after 8-12 weeks.

Safety & Limits

Upper Safe Limit

No established UL; 1500 mg/day is the highest commonly studied short-term dose without serious adverse effects.

Cycling

Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data; avoid unless directed by a clinician

Hormone-sensitive cancers (breast, uterine, ovarian) — theoretical concern because it may alter estrogen recycling; discuss with an oncologist

Synergies

DIM

DIM shifts estrogen metabolism toward hydroxylated metabolites, while calcium D-glucarate may reduce deconjugation in the gut, so the pair is often used together for estrogen handling.

Updated Invalid Date