howtosupplement
Mood/Sleep/Inflammation

CBD

Non-intoxicating cannabinoid studied for anxiety, sleep, and pain in adults seeking relief without a high.

CBD

CBD

42
score
C
evidence
Caution
risk

Proven Benefits

01Reduces anxiety symptoms
02May improve sleep quality
03May reduce chronic pain
04May lower inflammation
05May reduce PTSD symptoms

Chemical Forms

Recommended
  • CBD isolate
  • Broad-spectrum CBD
  • Full-spectrum CBD (contains trace THC)
Avoid
  • Unlabeled 'hemp seed oil' (contains negligible CBD)
  • Products without a Certificate of Analysis (COA)
Expert Note

CBD isolate contains only CBD; broad-spectrum keeps other hemp cannabinoids without THC; full-spectrum includes trace THC, which can matter for drug testing. Hemp seed oil contains essentially no CBD. Because product quality varies widely, a batch-specific COA is more important than the front-label claim.

Protocol

Amount
25-150 mg
Frequency
Once daily or split into 2 doses
When
With a meal containing fat to improve absorption; evening if it makes you drowsy.

Condition-Based Dosing

Generalized or social anxiety
100-300 mg daily
Sleep-onset or maintenance insomnia
25-100 mg in the evening
Chronic neuropathic pain
50-150 mg daily as adjunct

Safety & Limits

Upper Safe Limit
No official UL; short-term studies have used up to 1500 mg/day, but higher doses increase sedation, diarrhea, and liver-enzyme risk.
Cycling
Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data
Active liver disease or elevated ALT/AST — higher risk of enzyme elevations
Warfarin, clobazam, or other narrow-therapeutic-index CYP3A4/CYP2C19 drugs — interaction risk
Known cannabis or sesame allergy — hypersensitivity risk

Avoid Combining With

  • ✕Alcohol (additive sedation and cognitive impairment)
  • ✕CYP3A4/CYP2C19 medications (CBD inhibits metabolism and may raise drug levels)
  • ✕Grapefruit juice (adds to CYP3A4 interaction risk)
  • ✕Sedatives and benzodiazepines (additive CNS depression)
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