howtosupplement
Longevity

Fisetin

Flavonoid from strawberries and other fruits studied as a senolytic to clear aging cells and reduce inflammation; human evidence is limited.

Fisetin

Fisetin

38
score
C
evidence
Caution
risk

Proven Benefits

01May reduce senescence markers
02May lower inflammatory markers
03May improve physical function
04May support cognition

Chemical Forms

Recommended
  • Fisetin
  • Liposomal fisetin
  • Fisetin-galactomannan complex (Novusetin)
Avoid
  • Plain fisetin without bioavailability enhancement (poor absorption)
Expert Note

Fisetin has low oral bioavailability because it is rapidly glucuronidated and sulfated after oral dosing. Liposomal and galactomannan products are intended to raise exposure, but human comparative data are still sparse.

Protocol

Amount
20 mg/kg bodyweight
Frequency
Once daily for 2 consecutive days per month
When
With a meal containing fat to improve absorption.

Condition-Based Dosing

Adults 50+ in senolytic trial protocols
20 mg/kg/day for 2 consecutive days per month

Safety & Limits

Upper Safe Limit
No official UL; 20 mg/kg/day pulsed dosing has been used short-term without serious adverse events.
Cycling
2 days on, 28 days off; avoid continuous daily use long-term.

Contraindications

Bleeding disorders or anticoagulants/antiplatelets — theoretical bleeding risk
Pregnancy or breastfeeding — insufficient safety data
Scheduled surgery — stop 2 weeks before due to theoretical bleeding risk
Active chemotherapy — consult oncologist; interactions are uncertain
Updated Invalid Date