Heart/Inflammation/Beauty

Grape Seed Extract

Antioxidant-rich extract from grape seeds studied for blood pressure, cholesterol, and skin resilience in adults with metabolic risk factors.

Grape Seed Extract

Antioxidant-rich extract from grape seeds studied for blood pressure, cholesterol, and skin resilience in adults with metabolic risk factors.

score

evidence

Caution

risk

Proven Benefits

01Lowers blood pressure

02May reduce LDL cholesterol

03May ease venous symptoms

04May improve endothelial function

05May lower CRP and oxidative stress

06May protect skin from UV damage

Chemical Forms

Recommended

Standardized grape seed extract (80-95% proanthocyanidins)

Avoid

Generic 'grape extract' without standardization
Whole grape powder (low OPC content)

Expert Note

Clinical trials typically use extracts standardized to 80-95% proanthocyanidins. Non-standardized forms or whole grape powders contain variable and often low OPC levels, making dose-response unpredictable and likely subtherapeutic.

Protocol

Amount

150-400 mg

Frequency

Once daily

When

With a meal to improve absorption and reduce stomach upset.

Safety & Limits

Upper Safe Limit

800 mg/day (highest studied dose in trials; no official UL established)

Cycling

Safe for continuous use

Contraindications

Anticoagulant or antiplatelet therapy — may increase bleeding risk

Bleeding disorders — possible additive antiplatelet effects

Scheduled surgery — stop 2 weeks prior due to bleeding risk

Pregnancy or breastfeeding — insufficient safety data

Avoid Combining With

✕Anticoagulant/antiplatelet drugs (additive bleeding risk — check with clinician)
✕Iron supplements (polyphenols may reduce iron absorption — separate by 2+ hours)

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