Mobility/Performance/Cognition

Idebenone

Synthetic antioxidant similar to CoQ10 studied for vision loss in Leber's hereditary optic neuropathy and neurological function in Friedreich's ataxia.

Idebenone

Synthetic antioxidant similar to CoQ10 studied for vision loss in Leber's hereditary optic neuropathy and neurological function in Friedreich's ataxia.

score

evidence

Caution

risk

Proven Benefits

01Slows LHON vision loss

02Improves Friedreich's symptoms

03May reduce mitochondrial fatigue

04May slow cognitive decline

Chemical Forms

Recommended

Free form idebenone

Avoid

Proprietary blends with undisclosed idebenone dose

Expert Note

Idebenone is a single synthetic quinone compound. Absorption is enhanced by co-administration with dietary fat. Supplement blends that do not disclose the exact amount of idebenone should be avoided.

Protocol

Amount

900 mg

Frequency

Divided into 3 daily doses with meals

When

With meals containing fat to improve absorption; divided doses reduce gastrointestinal upset.

Condition-Based Dosing

Leber hereditary optic neuropathy (LHON)

900 mg daily in 3 divided doses— Based on pivotal LHON trials; use under specialist supervision.

Friedreich's ataxia

5 mg/kg daily divided into 2-3 doses— Mixed trial results; consult a neurologist.

Healthy adults without mitochondrial disease

Not recommended— No proven benefit and limited long-term safety data.

Safety & Limits

Upper Safe Limit

900 mg/day (highest dose studied in LHON trials; no official UL)

Cycling

Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data

Severe hepatic impairment — metabolism may be altered

Known allergy to benzoquinone derivatives

Avoid Combining With

✕Alcohol (may exacerbate mitochondrial oxidative stress)
✕Cigarette smoking (increases oxidative stress, counteracting mechanism)

Updated Invalid Date