howtosupplement
Cognition/Mood/Sleep

Noopept

Synthetic nootropic peptide studied for mild cognitive impairment, with limited evidence in healthy adults.

Noopept

Noopept

36
score
C
evidence
Caution
risk

Proven Benefits

01May improve cognition in MCI
02May aid brain injury recovery
03May reduce anxiety
04May improve sleep quality

Chemical Forms

Recommended
  • Oral capsules
  • Powder
Avoid
  • Unverified liquid solutions (purity concerns)
  • Megadosed racetam stacks (unstudied interactions)
Expert Note

Noopept has been studied almost exclusively as an oral tablet or capsule. Sublingual and liquid preparations lack bioavailability and safety data. Combining with other racetams has not been studied and may increase side effects.

Protocol

Amount
10-30 mg
Frequency
Once or twice daily
When
Morning or early afternoon with food; avoid late-day dosing due to potential insomnia.

Condition-Based Dosing

Mild cognitive impairment or cerebrovascular insufficiency
10-20 mg twice daily for 8-12 weeks
Healthy adults seeking cognitive effects
10-30 mg once daily

Safety & Limits

Upper Safe Limit
60 mg/day (highest dose studied in clinical trials; no official UL)
Cycling
Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient safety data
Bipolar disorder or psychotic disorders — theoretical risk of mood destabilization
Epilepsy or seizure disorders — may alter glutamate signaling
Use with other cognitive enhancers — additive effects unknown

Avoid Combining With

  • ✕Alcohol (may impair cognitive benefits and add sedation)
  • ✕Other racetams or ampakines (additive effects, unstudied combinations)
Updated Invalid Date