howtosupplement
Cognition

Oxiracetam

Synthetic racetam nootropic studied for memory support in age-related cognitive decline, with very limited evidence in healthy adults.

Oxiracetam

Oxiracetam

38
score
C
evidence
Caution
risk

Proven Benefits

01May improve memory in dementia
02May support attention in elderly
03May reduce cognitive fatigue
04May improve processing speed

Chemical Forms

Recommended
  • Oxiracetam powder
  • Oxiracetam capsules
Avoid
  • Unverified liquid solutions or bulk powders without independent assay
Expert Note

Oxiracetam is a single synthetic molecule; absorption is not meaningfully altered by salt or delivery form in available data. Capsules and measured powders are preferred over unverified liquids to ensure accurate dosing.

Protocol

Amount
800-2400 mg
Frequency
Split into 2-3 doses
When
Morning and early afternoon; avoid late-day dosing due to potential insomnia.

Safety & Limits

Upper Safe Limit
2400 mg/day (highest dose studied in trials; no official UL established)
Cycling
Safe for continuous use

Contraindications

Pregnancy or breastfeeding — no safety data
Severe renal impairment — reduced clearance expected
Bipolar disorder or psychotic disorders — theoretical risk of overstimulation

Synergies

Choline

Choline may support acetylcholine synthesis and reduce headache risk, though human synergy data for oxiracetam specifically is sparse.

Avoid Combining With

  • ✕Alcohol (may blunt cognitive effects and add neurodepressant action)
  • ✕Sedatives (theoretical antagonism of mild stimulatory effects)
Updated Invalid Date