Cognition/Performance/Mood
Phenylpiracetam
Synthetic racetam compound studied for cognitive and fatigue effects in cerebrovascular insufficiency, with limited human evidence.
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Phenylpiracetam
Synthetic racetam compound studied for cognitive and fatigue effects in cerebrovascular insufficiency, with limited human evidence.
42
C
evidenceCaution
riskProven Benefits
01May improve cognitive function
02May reduce fatigue
03May support post-stroke recovery
04May reduce depressive symptoms
Chemical Forms
Recommended
- Racemic phenylpiracetam
Avoid
- Unverified bulk powders (purity and dosing risks)
Expert Note
The racemic mixture is the standard form used in Russian clinical studies; enantiopure products lack comparative human trials. Because of its high potency and stimulant properties, verified purity and precise dosing are essential, making unregulated bulk powders risky.
Protocol
Amount
100-200 mg
Frequency
Once daily, morning
When
Morning, with food to reduce GI upset; avoid afternoon or evening due to stimulant effects.
Condition-Based Dosing
Cognitive decline or asthenia (clinical populations)
100-200 mg once daily, up to 200 mg twice daily under medical supervision
Healthy adults seeking nootropic effects
100 mg once daily
Safety & Limits
Upper Safe Limit
No official UL; do not exceed 600 mg/day (highest dose in Russian trials)
Cycling
2-3 weeks on, 1-2 weeks off; or use only as needed to limit tolerance.
Contraindications
Pregnancy or breastfeeding — no safety data available
Bipolar disorder or psychosis — stimulant effects may trigger mania
Hypertension or cardiac arrhythmias — may increase cardiovascular strain
Epilepsy — theoretical seizure threshold lowering
MAOIs or other stimulants — risk of hypertensive crisis or overstimulation
Severe liver or kidney disease — insufficient metabolism data
Synergies
Racetams may increase acetylcholine demand; concurrent choline intake may reduce the risk of headaches.
Avoid Combining With
- ✕Alcohol (may compound CNS side effects or impair judgment)
- ✕Caffeine and other stimulants (additive cardiovascular and CNS load)
- ✕Evening dosing (causes insomnia due to psychostimulant properties)
Updated Invalid Date