howtosupplement
Heart/Mobility/Women

Pine Bark Extract

Standardized maritime pine bark extract rich in procyanidins, studied for venous insufficiency, joint comfort, and circulation in adults.

Pine Bark Extract

Pine Bark Extract

50
score
B
evidence
Caution
risk
Use with caution

This supplement may interact with medications, medical conditions or sensitive populations. Review safety before use.

Quick Take

Worth considering for chronic venous insufficiency or knee osteoarthritis; benefits for general wellness are modest and niche.

Pine bark extract is a concentrated source of oligomeric proanthocyanidins (OPCs) derived primarily from the French maritime pine (Pinus pinaster). It acts as an antioxidant and modulates vascular permeability, nitric oxide production, and inflammatory signaling. Clinical trials show the strongest evidence for reducing symptoms of chronic venous insufficiency, such as leg swelling and skin changes. Smaller studies suggest modest support for knee osteoarthritis discomfort and menstrual pain.

Proven Benefits

01
Improves chronic venous insufficien
02
Lowers blood pressure modestly
03
Reduces osteoarthritis knee pain
04
Reduces menstrual pain
05
May reduce travel-related leg edema
06
May improve endothelial function
07
May reduce post-exercise muscle cra

Protocol

Amount
100–200 mg
Frequency
Once or twice daily
When
With meals to reduce stomach upset

Onset Time

4-8 weeks for vascular and joint symptom relief

Who Should Consider

Adults with chronic venous insufficiency
People with mild knee osteoarthritis
Women with primary dysmenorrhea
Adults seeking circulatory support

How It Works

The procyanidins in pine bark extract scavenge free radicals, enhance nitric oxide-mediated vasodilation, and inhibit pro-inflammatory enzymes such as COX-2 and 5-LOX. These actions improve capillary integrity and blood flow while reducing oxidative stress in connective tissues.

Updated 5/19/2026