Sleep/Cognition/Inflammation

PQQ

Redox cofactor marketed for mitochondrial support that may modestly improve sleep and mental fatigue in healthy adults.

PQQ

Redox cofactor marketed for mitochondrial support that may modestly improve sleep and mental fatigue in healthy adults.

score

evidence

Caution

risk

Proven Benefits

01May improve sleep quality

02May reduce mental fatigue

03May improve attention/memory

04May lower hs-CRP

05May reduce oxidative stress

Chemical Forms

Recommended

PQQ disodium salt

Avoid

Unspecified PQQ form (hard to match to clinical studies)

Expert Note

Most human research has used PQQ disodium salt, a stable and well-defined supplemental form. When the label does not specify the form, it is harder to know whether the product matches the dose and material used in clinical trials.

Protocol

Amount

10-20 mg

Frequency

Once daily

When

With breakfast or lunch; take earlier in the day if it feels mildly activating.

Condition-Based Dosing

Healthy adults using it for general wellness or fatigue

10-20 mg daily for 6-8 weeks, then reassess.— Most human studies use 20 mg/day; benefits beyond this range are not well established.

Safety & Limits

Upper Safe Limit

20 mg/day (practical ceiling based on the best-studied adult human trials; no official UL established)

Cycling

Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient human safety data

Kidney or liver disease — limited human safety data, use only with clinician guidance

Active cancer treatment — interaction data are lacking; use only with oncology approval

Synergies

CoQ10

PQQ appears to influence mitochondrial biogenesis signaling, while CoQ10 helps shuttle electrons in the mitochondrial respiratory chain; small human cognition trials often use the pair.

Updated Invalid Date