howtosupplement
Heart/Weight/Longevity

Pterostilbene

Polyphenol related to resveratrol with limited human evidence and no clearly proven benefit for healthy adults.

Pterostilbene

Pterostilbene

18
score
D
evidence
Caution
risk

Proven Benefits

01May lower blood pressure
02May support glucose control
03May affect LDL cholesterol

Chemical Forms

Recommended
  • trans-Pterostilbene
Avoid
  • Proprietary blends without exact pterostilbene dose
  • Multi-ingredient longevity formulas that obscure standalone effects
Expert Note

Human studies are limited and generally use trans-pterostilbene as the isolated active form. Because the evidence base is already thin, products that hide the actual dose or combine it with multiple actives make the results even harder to interpret.

Protocol

Amount
50-125 mg
Frequency
Once or twice daily
When
Any time of day — consistency matters more than timing.

Condition-Based Dosing

Healthy adults using it experimentally
50 mg daily to start; do not escalate without a clear reason.

Safety & Limits

Upper Safe Limit
No established UL; long-term safe ceiling is not well defined in humans.
Cycling
Safe for continuous use

Contraindications

Pregnancy or breastfeeding — insufficient human safety data
Lipid disorders — some human data suggest LDL cholesterol may rise
Diabetes medications — possible additive glucose-lowering effect, though human evidence is limited
Active liver disease — insufficient long-term safety data

Avoid Combining With

  • ✕Multi-ingredient stacks (make benefits and side effects impossible to attribute)
Updated Invalid Date