howtosupplement
Inflammation/Immunity/Women

Serrapeptase

Proteolytic enzyme used to reduce post-operative swelling and ease chronic sinusitis symptoms, with limited but promising anti-inflammatory evidence.

Serrapeptase

Serrapeptase

42
score
C
evidence
Caution
risk

Proven Benefits

01Reduces post-operative swelling
02Eases chronic sinusitis symptoms
03Reduces dental pain and swelling
04May reduce thick respiratory mucus
05May ease fibrocystic breast pain

Chemical Forms

Recommended
  • Serrapeptase (enteric-coated)
  • Serratiopeptidase
Avoid
  • Non-enteric-coated serrapeptase (destroyed by stomach acid)
Expert Note

Serrapeptase is a protein that is rapidly degraded by stomach acid. Enteric-coated tablets or capsules are essential to protect the enzyme until it reaches the intestines, where absorption occurs. Non-coated forms offer negligible systemic activity.

Protocol

Amount
10-30 mg
Frequency
Once or twice daily, 30 minutes before meals
When
On an empty stomach, 30 minutes before meals or 2 hours after eating, to avoid proteolytic degradation by food proteins.

Condition-Based Dosing

Post-operative swelling or dental inflammation
20-30 mg twice daily for 1-2 weeks
Chronic sinusitis or thick respiratory mucus
10-20 mg twice daily for 2-4 weeks

Safety & Limits

Upper Safe Limit
No established tolerable upper limit; doses above 60 mg/day (120,000 SPU) lack safety data.
Cycling
Safe for continuous use

Contraindications

Anticoagulant or antiplatelet therapy — theoretical bleeding risk due to fibrinolytic activity
Recent surgery with bleeding risk — proteolytic activity may affect clotting
Pregnancy and breastfeeding — insufficient safety data
Soy or bacterial protein allergy — derived from Serratia fermentation media

Avoid Combining With

  • ✕Food or protein shakes within 1 hour (competes for absorption and may degrade the enzyme)
  • ✕Anticoagulant medications like warfarin (theoretical increased bleeding risk — consult clinician)
Updated Invalid Date