howtosupplement
Longevity/Inflammation/Heart

Sulforaphane

Broccoli-derived compound that activates cellular antioxidant defenses and has been studied for prostate health, inflammation, and metabolic markers.

Sulforaphane

Sulforaphane

52
score
C
evidence
Caution
risk

Proven Benefits

01May retrasar duplicación PSA
02May enhance pollutant detox
03May lower hs-CRP and IL-6
04May improve endothelial function
05May reduce gastric inflammation
06May lower oxidative stress
07May lower blood pressure

Chemical Forms

Recommended
  • Stabilized sulforaphane
  • Glucoraphanin with myrosinase
  • Broccoli seed extract standardized to glucoraphanin
Avoid
  • Glucoraphanin alone without myrosinase (poor conversion to sulforaphane)
  • Whole broccoli powder (low sulforaphane yield)
Expert Note

Sulforaphane is unstable; many supplements contain only glucoraphanin, which requires the enzyme myrosinase to convert. Products pairing glucoraphanin with myrosinase yield significantly more active sulforaphane. Stabilized sulforaphane extracts bypass this conversion issue.

Protocol

Amount
30-60 mg glucoraphanin with myrosinase, or 10-20 mg stabilized sulforaphane
Frequency
Once daily
When
With a meal to reduce stomach upset; morning often preferred.

Condition-Based Dosing

Men with biochemical recurrence of prostate cancer
60 mg glucoraphanin daily (approx. 100 µmol)
General antioxidant support in healthy adults
30 mg glucoraphanin daily
H. pylori infection support
50-100 mg glucoraphanin daily for 4-8 weeks

Safety & Limits

Upper Safe Limit
No established UL; doses up to 200 µmol (~35 mg sulforaphane) daily have been used in short-term trials without serious adverse effects.
Cycling
Safe for continuous use

Contraindications

Hypothyroidism or iodine deficiency — high doses of cruciferous extracts may reduce iodine uptake by the thyroid
Pregnancy and breastfeeding — insufficient safety data at supplemental doses
Warfarin or anticoagulants — some broccoli extracts contain vitamin K; monitor INR

Synergies

Vitamin D3

Vitamin D3 and sulforaphane may have complementary anti-cancer effects in prostate tissue, though clinical synergy is unproven.

Avoid Combining With

  • ✕Heat during cooking (destroys myrosinase enzyme in food sources)
  • ✕Proton pump inhibitors like omeprazole (may reduce conversion of glucoraphanin in the gut)
  • ✕Antacids and high-pH environment (impairs myrosinase activity needed for conversion)
Updated Invalid Date