Cognition/Heart

Vinpocetine

Synthetic periwinkle alkaloid studied for memory and cerebral blood flow in age-related cognitive decline, with mixed and dated evidence.

Vinpocetine

Synthetic periwinkle alkaloid studied for memory and cerebral blood flow in age-related cognitive decline, with mixed and dated evidence.

score

evidence

Caution

risk

Proven Benefits

01May improve memory in age-related d

02May increase cerebral blood flow

03May improve attention and concentra

04May improve reaction time

05May lower blood pressure

Chemical Forms

Recommended

Vinpocetine

Avoid

Vincamine (less bioavailable, fewer human trials)
Raw Vinca minor herb (unstandardized alkaloid content)

Expert Note

Vinpocetine is the standardized ester of vincamine with superior oral bioavailability and the bulk of clinical research. Vincamine has unpredictable pharmacokinetics, and raw periwinkle herb lacks consistent alkaloid levels.

Protocol

Amount

5-10 mg

Frequency

2-3 times daily

When

With meals to reduce gastrointestinal upset.

Safety & Limits

Upper Safe Limit

60 mg/day (highest dose evaluated in chronic studies; no official UL established)

Cycling

Safe for continuous use

Contraindications

Pregnancy or trying to conceive — animal studies suggest teratogenic potential

Bleeding disorders or use of blood thinners — may increase bleeding risk

Hypotension or concurrent blood pressure medications — risk of excessive lowering

Upcoming surgery — discontinue at least 2 weeks prior due to bleeding risk

Avoid Combining With

✕Anticoagulant or antiplatelet medications (theoretical increased bleeding risk — consult clinician)
✕Antihypertensive drugs (may additively lower blood pressure)

Updated Invalid Date