Hormonal/Weight/Cognition

Yohimbine

Alpha-2 adrenergic antagonist sometimes used for erectile dysfunction and fat loss, but with significant safety concerns and mixed evidence.

Yohimbine

Alpha-2 adrenergic antagonist sometimes used for erectile dysfunction and fat loss, but with significant safety concerns and mixed evidence.

score

evidence

Unsafe

risk

Proven Benefits

01May improve erectile function

02May reduce body fat

03May increase sexual arousal

04May increase acute alertness

Chemical Forms

Recommended

Yohimbine HCl
Standardized yohimbe bark extract (2-3% yohimbine)

Avoid

Raw yohimbe bark powder (variable alkaloid content)
Proprietary 'yohimbe complex' blends (dose opacity)

Expert Note

Yohimbine HCl provides a precise, known dose of the active alkaloid. Standardized bark extract offers slightly less precision but is commonly studied. Raw bark powders vary wildly in yohimbine content and may contain other alkaloids, making side effects unpredictable. Proprietary blends often obscure the actual yohimbine dose, increasing overdose risk.

Protocol

Amount

5-10 mg per dose

Frequency

Up to 3x daily (ED); single morning dose (fat loss)

When

On an empty stomach; avoid late-day dosing due to stimulant effects

Condition-Based Dosing

Erectile dysfunction (psychogenic)

5-10 mg three times daily— Higher doses increase side effect risk without clear added benefit.

Fat loss protocols

0.2 mg/kg bodyweight once daily before fasted activity— Start at the low end; cardiovascular side effects are common.

Safety & Limits

Upper Safe Limit

No established UL; doses above 30 mg/day increase risk of hypertension, tachycardia, and anxiety significantly

Cycling

Use only for short periods under supervision; avoid continuous daily use beyond 2-3 weeks due to cardiovascular and anxiety risks

Contraindications

Cardiovascular disease, hypertension, or arrhythmia — yohimbine raises heart rate and blood pressure

Anxiety disorders or panic disorder — can precipitate panic attacks

Bipolar disorder or schizophrenia — may worsen manic or psychotic symptoms

MAOIs or tricyclic antidepressants — risk of hypertensive crisis

Pregnancy and breastfeeding — contraindicated due to lack of safety data and stimulant effects

Kidney or liver disease — reduced clearance and higher toxicity risk

Avoid Combining With

✕Food (delays absorption — take on empty stomach)
✕Caffeine and other stimulants (additive blood pressure and anxiety risk)
✕Antihypertensive medications (pharmacological opposition — yohimbine raises BP)

Updated Invalid Date